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10.1093/eurheartj/ehac320 [DOI] [PMC free article] [PubMed] [Google Scholar] 380.Huang, X

Elevated Ins levels have been reported in 1 H-MRS studies, including an increase in the PFC of patients diagnosed with bipolar depression 84

The IGF-1R may contribute to tamoxifen resistance by two possible mechanisms: 1) IGF-mediated activation of AKT and subsequent estrogen-independent activation of ER [54] or 2) a direct interaction between ER and IGF-1R [55]